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Multiscale analysis of lymphatic muscle pumping

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Lymphatic Forum 2019



 Exploring the Lymphatic Continuum

May 30-June 1, 2019
AT&T Conference Center Austin, TX


Preliminary Program


Thursday, May 30, 2019

Clinical Aspects of Lymphatic Pathologies and Patient Perspectives
Chair: Stanley Rockson, Stanford University

8:30am   Clinical cases discussed

Lymphatic Development and Remodeling
Chair: Mark Kahn, University of Pennsylvania


  Introduction by Session Chair


  Lymphatics in heart development


    Guillermo Oliver, Northwestern University


  Multiscale analysis of lymphatic muscle pumping


    James Moore, Imperial College London
11:35am    Leishmania Infection–Induced Lymphangiogenesis


    Tiffany Weinkopff, University of Arkansas for Medical Sciences


  Short Talk: Nucleoside-Modified VEGFC mRNA Induces Organ-Specific Lymphatic Growth and Reverses Experimental Lymphedema


    Zoltan Jakus, Semmelweis University and Hungarian Academy of Sciences


  Nano Talk: Lymphatic Mimicry Promotes Placental Spiral Artery Remodeling


    John Pawlak, University of North Carolina


  Nano Talk: Enhancing Lymphangiogenesis Ameliorates Chronic Heart Failure


    LouJin Song, Pfizer, Inc.
12:23pm                Lunch Break – on your own
1:45pm   Message from Dr. Griffin Rodgers, Director National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
      William Repicci, President and CEO of LE&RN

Lymph and Interstitial Fluid "omic" Profiles in Health and Disease
Chair: Laura Santambrogio, Albert Einstein School of Medicine

1:55pm   Introduction by Session Chair
2:00pm    Continuous release of Beta cell peptides primes the immune system for autoimmune diabetes
      Emil Unanue, Washington University School of Medicine
2:25pm    Identification of pathogen peptidome targets in biological fluids to diagnose disease and identify specific pathogen species
      Tony Hu, Arizona State University
2:50pm   Short Talk: Ultra high-frequency ultrasound: a new and highly accurate tool for visualization of lymphatic vessels
      Guido Giacalone, AZ Sint-Maarten
3:03pm    Nano Talk: Altered lymphatic transport and metabolism of chylomicrons in Crohn’s disease
      Li-Hao Huang, Washington University School of Medicine

Mechanobiology of Lymphatic Structure and Function
Chair: Michael Davis, University of Missouri
Co-sponsored by the Microcirculatory Society

3:25pm   Introduction by Session Chair
3:30pm    The tale of two shear stress activated signaling pathways
      Sathish Srinivasan, Oklahoma Medical Research Foundation
3:55pm    Effects of pulmonary lymph flow on lymphatic endothelium
      Sanjeev Datar, University of California, San Francisco
4:20pm   Dissecting the transcriptional control of lymphatic endothelial cell identity
      Natasha Harvey, University of South Australia
4:45pm   Short Talk: The role of Foxo1 in Lymphatic Valve Formation
      Ying Yang, University of South Florida
4:58pm    Short Talk: VE-cadherin Is Required for Lymphatic Valve Formation and Maintenance
      Joshua Scallan, University of South Florida
5:11pm    Nano Talk: Ex vivo and In Vivo Entrainment of Lymphatic Contractions to Oscillatory Pressure Gradients
      Anish Mukherjee, Georgia Institute of Technology
5:16pm    Nano Talk: Co-regulation of Lymphangiogenesis by Mechanical and Biochemical Cues
      Laura Alderfer, University of Notre Dame
5:21pm    Nano Talk: An in vitro study of the morphological and biochemical responses of lymphatic endothelial cells in response to spatiotemporally varying wall shear stress
       Elefttheria Michalaki, Stanford University
5:26pm    Dinner on your own  
Poster Session I – 7:30-9:30pm
Friday, May 31, 2019

Mixed Vascular (lymphatic-venous) Anomalies
Chair: Peter Mortimer, St. George’s University of London

8:30am   Introduction by Session Chair
8:35am    Molecular Genetics of Vascular Malformations
      Miikka Vikkula, Institut de Duve
9:00am   Complex Vascular Malformations with Lymphatic Involvement
      Francine Blei, Northwell Health
9:25am   Medical management of lymphatic anomalies: Sirolimus and beyond
      Denise Adams, Boston Children’s Hospital
9:50am    Short Talk: RAS-MAPK and PI3K-AKT-mTOR pathway inhibitors in a zebrafish model of lymphatic malformations associated with the KRAS p.G12D mutation
      Sarah Sheppard, Children's Hospital of Philadelphia
10:03am    Nano Talk: Mutations in genes involved in MAPK pathway cause lymphatic anomalies
       Dong Li, Children's Hospital of Philadelphia

Trainee/Young Investigators Session
Co-Chairs: Jorge Castorena Gonzalez, University of Missouri and Wenjing Xu, University of North Carolina at Chapel Hill 

 10:25am   Introduction by Session Chairs
 10:30am   Loss of lymphatic endothelial Foxc2 in adult protects against diet-induced obesity by promoting lymphangiogenesis  
      Yang Lee, Harvard Medical School/Boston Children's Hospital 
 10:55am   MicroRNA-mediated control of developmental lymphangiogenesis  
      Hyun Min Jung, NICHD/NIH
 11:20am   Dysfunction of collecting liver lymphatics during the progression of extrahepatic cholestasis  
      April O'Brien, Texas A&M Health Science Center 
11:45am    Nanofibrillar scaffold with plated adipose derived stem cells, its use for lymphedema treatment in rats, and path for clinical application  
      Peter Tabada, Fibralign Corp 
12:10pm               Lunch Break – on your own
1:45pm   Message from Dr. Gary H. Gibbons, M.D.,  Director of the National Heart, Lung, and Blood Institute (NHLBI)
      William Repicci, LE&RN 

Lymphatic Muscle and Lymph Flow
Chair: Brandon Dixon, Georgia Institute of Technology
Co-sponsored by the Japanese Society of Lymphology

1:55pm   Introduction by Session Chair
2:00pm    Water intake accelerates mesenteric lymph flow and the total flux of long-chain fatty acids
      Toshio Ohhashi, Shinshu University
2:25pm    SR calcium release accelerates lymphatic muscle cell pacemaking through activation of Ano1
      Scott Zawieja, University of Missouri
2:50pm    Early rescue of lymphatic function limits atherosclerosis progression in Ldlr-/- mice
      Catherine Martel, Montreal Heart Institute

Short Talk: Muscle cells on the lymphatics should be referred as lymphatic muscle cells not as lymphatic smooth muscle cells

      Mariappan Muthuchamy, Texas A&M University
3:28pm    Nano Talk: Role calcineurin/NFAT inhibitors on contractility of collecting lymphatic vessels
      Zhanna Nepiyushchikh, Georgia Institute of Technology
 3:33pm   Nano Talk: Endothelium-dependent mechanisms of lymphatic dysfunction in metabolic syndrome and type-2 diabetes associated with obesity
      Jorge Castorena-Gonzalez, University of Missouri
3:38pm    Nano Talk: Lymphatic-targeting nanoparticles for mechanistically enhancing contractions of collecting lymphatic vessels
      Kim To, Georgia Institute of Technology

Quantitative Analysis of Lymphatic Structure and Function
Chair: James Moore, Imperial College London

4:00pm   Introduction by Session Chair
4:05pm    Physical and electrical analogs of multi-lymphangion systems
      James Baish, Bucknell University
4:30pm    In vivo imaging of the outflow of cerebrospinal fluid through lymphatic vessels
      Steven Proulx, Swiss Federal Institute of Technology
4:55pm    Growth and remodeling in collecting lymphatic vessels and the consequence to function
      Brandon Dixon, George Institute of Technology
5:20pm    Short Talk: Paracellular and energy-dependent transport as functional components of lymphatic physiology of brain meninges
      Liudmila Romanova, Rush University Medical Center
5:33pm    Nano Talk: Inadequate Lymphatic Reserve in Heart Failure with Preserved Ejection Fraction
      Giacomo Rossitto, University of Glasgow
5:38pm    Nano Talk: Chemokine Transport within the Lymphatic System: Toward an Integration of Cellular and Transport Phenomena
      Daniel Watson, Imperial College
5:45pm    Dinner on your own  
Poster Session II – 7:30-9:30pm
Saturday, June 1, 2019

Novel Insights on Mechanisms of Lymph Transport
Chair: Sanjukta Chakraborty, Texas A&M College of Medicine

8:30am   Introduction by Session Chair
8:35am    Histamine and lymphatics - from health to disease
      Anatoliy Gashev, Texas A&M College of Medicine
9:00am    Delivering therapeutics to targets within the lymphatics
      Eva Sevick, University of Texas Health Science Center at Houston
9:25am    Latest advances in research on lymphatic anomalies with bone involvement
      Michael Dellinger, UT Southwestern Medical Center
9:50am    Lymphatics in our unhealthy lifestyles
      Joseph Rutkowski, Texas A&M Health Science Center

Inflammation and the Lymphatic-immune Interface
Chair: Mariappan Muthuchamy, Texas A&M Health Science Center

10:30am   Introduction by Session Chair
10:35am    Leukocyte entry and migration through afferent lymphatic vessels
      Cornelia Halin, ETH Zurich
11:00am    Lymph-borne antigens and dendritic cells in the generation of T cell responses
      Michael Gerner, University of Washington
11:25am    Immune consequences of lymphatic alterations during intestinal inflammation
      Pierre von der Weid, University of Calgary

Short Talk: Lymph node formation and B cell homeostasis require IKKa in distinct endothelial cell-derived compartments

      Michael J. May, University of Pennsylvania
 12:03pm   Short Talk: Chronic liver disease in humans causes expansion and differentiation of liver lymphatic endothelial cells  
      Matthew A. Burchill, University of Colorado - Anschutz Medical Campus

Nano Talk: Mechanisms of immunotherapy potentiation by lymphangiogenic tumors  

      Lambert Potin, University of Chicago 
12:21pm   Nano Talk: Lymphatic-mediated egress of tumor-specific CD8+ T cells limits anti-tumor immunity in melanoma
      Maria Steele, Oregon Health & Science University
12:26pm              Lunch Break – on your own

Role of Lymphatics in Infectious and Parasitic Diseases
Chair: Tim Padera, Massachusetts General Hospital

1:45pm   Introduction by Session Chair
1:50pm    Doxycycline trial for filarial lymphedema
      Philip Budge, Washington University in St. Louis
2:15pm    Effects of MRSA infections on lymphatic function
      Tim Padera, Massachusetts General Hospital
2:40pm    Lymphatic transport in cutaneous viral infection
      Amanda Lund, Oregon Health & Science University
3:05pm   Short Talk: PD-L1 expression by lymphatic endothelial cells; more than just a signal to T cells
      Beth A. Tamburini, University of Colorado Anschutz Medical Campus
3:18pm   Short Talk: Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels
      Witold Kilarski, University of Chicago

Lymphatic Tissue Engineering, Stem Cells and Nanoparticles
Chair: Melody Swartz, University of Chicago

3:45pm   Introduction by Session Chair
3:50pm    Tissue scaffolds for reconstruction of lymphatic vessels
      Stanley Rockson, Stanford University
4:15pm    Overcoming barriers to tumor lymphatic drug delivery
      Susan Thomas, Georgia Institute of Technology
4:40pm   Short Talk: Stromal vascular fraction derived vasculogenesis is associated with the formation of mosaic lymphatic/blood vessels
      Walter Lee Murfee, University of Florida
4:53pm   Nano-Talk: Nanoparticles for lymphatic-targeted nitric oxide delivery
      Lauren F. Sestito, Georgia Institute of Technology
4:58pm   Nano-Talk: Targeting antigen to lymph node lymphatic endothelial cells under steady-state to promote archiving and memory
      Chitavi D. Maulloo, University of Chicago 
Closing Session
5:30pm    Message from Kathy Bates LE&RN Spokesperson and Intro to Plenary Speaker
      William Repicci, LE&RN
5:40pm   Plenary Lecture: Translational medicine: the impact of lymphatic science
      Peter Mortimer, St. George’s University of London
6:30pm   Farewell Dinner and Award Ceremony 


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Translational medicine: the impact of lymphatic science

Co-Sponsored by:

This meeting is being supported in part by the following:

Additional Poster Award provided by:

Funding for this conference was made possible (in part) by R13HL147556 from the the National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the NIH; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.